Various elements of protein structure and function are taught throughout biology and biochemistry programs. Learning outcomes range from describing the primary structure to as advanced as explaining molecular details of structure-function relationships and mechanisms. Students often experience two-dimensional representations of proteins in textbooks and lectures; however, they are usually unable to use these images to grasp the spatial concepts being explained. In this workshop, we will look at multiple ways of overcoming this disconnect. In conjunction, we use molecular models, LEGO™ bricks and the protein visualisation software PyMOL to experience the wonder of the electron transport chain. Participants visualise ETC complexes with PyMOL and generate videos to explain mechanics and protein features. Using specific examples of complex I (NADH dehydrogenase) and complex V (ATP synthase) from the ETC to demonstrate various concepts and construct physical models in the session using molecular models and LEGO ™. Specifically, secondary structure, non-covalent interactions, metal ion coordination, reaction mechanism and conformation change. To reinforce the importance of these features, we link each feature to the function of these essential proteins. The workshop is targeted at those teaching protein structure/function to both majors and non-majors.
Keywords: protein structure, electron transport chain, models, protein function
University of Ottawa (2019)
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