Tested Studies in Laboratory Teaching, 2011, Volume 32
Abstract
This exercise is designed to teach every aspect of a genotyping project by using a Single Nucleotide Polymorphism (SNP) in the KIAA0319 gene that is known to be associated with dyslexia. Initially, students extract their own DNA and then set-up subsequent PCR reactions and restriction digests in order to determine their genotype. Concurrent exercises in Bioinformatics demonstrate how a genotyping protocol is designed, as well as how phenotype can vary due to a single base pair change. As a result, this exercise demonstrates the multitude techniques that a research scientist uses to investigate how SNPs contribute to human phenotypes.
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